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Targeting Thyroid Cancer PowerPoint Presentation

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Slide 1 - Targeting Thyroid Cancer
Slide 2 - Program Goal
Slide 3 - Thyroid Cancer Newly Detected 2013 (n=60,220)
Slide 4 - Follicular Cell Thyroid Cancer Deaths 2013 (n = 1850)
Slide 5 - Familial Syndromes
Slide 6 - Thyroid Cancer Treatment “Pyramid”
Slide 7 - Risk Stratification
Slide 8 - ppt slide no 8 content not found
Slide 9 - ppt slide no 9 content not found
Slide 10 - RAI-Refractory Disease
Slide 11 - Doxorubicin: Single-agent Activity
Slide 12 - Doxorubicin +/- Cisplatin
Slide 13 - Doxorubicin +/- Cisplatin: Results
Slide 14 - ppt slide no 14 content not found
Slide 15 - Targets in Thyroid Cancer
Slide 16 - VEGF and Thyroid Cancer
Slide 17 - Sorafenib
Slide 18 - Sorafenib University of Pennsylvania
Slide 19 - Sorafenib Results University of Pennsylvania
Slide 20 - Sorafenib Ohio State
Slide 21 - Sorafenib Results Ohio State
Slide 22 - Sorafenib Response Rates Ohio State vs Penn
Slide 23 - DECISION Study
Slide 24 - DECISION Study Results
Slide 25 - DECISION Study Response Rates
Slide 26 - Lenvatinib (E7080) Background
Slide 27 - Lenvatinib Response Rate
Slide 28 - Differentiated Thyroid Cancers Phase 2 Studies -- Multitargeted TKIs
Slide 29 - Summary of Angiogenesis Inhibition
Slide 30 - Genetic Alterations in Thyroid Cancer
Slide 31 - Concordance of Genetic Alterations in MAPK but Not PI3K Pathway Oncogenes
Slide 32 - Selumetinib (AZD6244)
Slide 33 - Selumetinib Response Rate
Slide 34 - ppt slide no 34 content not found
Slide 35 - Impact of Selumetinib on 124I Incorporation
Slide 36 - ppt slide no 36 content not found
Slide 37 - Responses for RAI-Treated Patients
Slide 38 - BRAF
Slide 39 - Vemurafenib
Slide 40 - Vemurafenib Response Rate
Slide 41 - Current Studies for BRAF Mutant Thyroid Cancer
Slide 42 - Summary of BRAF and MEK targets
Slide 43 - Medullary Thyroid Cancer
Slide 44 - Presentations of MCT
Slide 45 - MTC: Hereditary vs Sporadic?
Slide 46 - Hereditary MTC Until Proven Otherwise
Slide 47 - Sporadic MTC Frequency of RET Mutations
Slide 48 - Vandetanib (ZD6474)
Slide 49 - Vandetanib: Randomized Phase 3 Trial
Slide 50 - Vandetanib: PFS
Slide 51 - Vandetanib: Objective Tumor Assessments
Slide 52 - Cabozantinib (XL184)
Slide 53 - Cabozantinib: Phase 3 Study Design (EXAM)
Slide 54 - Cabozantinib: PFS
Slide 55 - Summary of Medullary Thyroid Cancer
Slide 56 - Abbreviations
Slide 57 - Abbreviations (cont)
Slide 58 - Abbreviations (cont)
Slide 59 - References
Slide 60 - References (cont)
Slide 61 - References (cont)
Slide 62 - References (cont)
Slide 63 - References (cont)
Slide 64 - References (cont)
Slide 65 - References (cont)