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Women Breast Cancer

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Women Breast Cancer PowerPoint Presentation

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Published on : Mar 14, 2014
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Slide 1 - Breast Cancer Professor Arnold Hill Wed 26th October 2011
Slide 2 - Breast Cancer Breast Cancer in Ireland If you find a lump… Treatments for breast cancer Latest breast cancer treatments Reorganisation of breast cancer services
Slide 3 - Breast Cancer in Ireland Each year over 2,300 women & 25 men diagnosed with breast cancer in Ireland Each year nearly 700 people die from breast cancer in Ireland Lifetime risk: 1 in 10 women
Slide 4 - New symptoms to seek medical opinion on… Breast lump Nipple discharge Nipple inversion Breast skin changes Strong family history Mother, sister, grandmother, aunt
Slide 5 - Risk Factors Increasing age Exposure to estrogens Environmental/lifestyle Family History Genetic abnormality (5-10%) BRCA1/2 Sister Study National Institute of Environmental Health Sciences 50,000 women followed for 10 years
Slide 6 - Screening 50-64 years Every 2 years
Slide 7 - Imaging >35 years of age < 35 years of age
Slide 8 - Breast Cancer Breast Cancer in Ireland If you find a lump… Treatments for breast cancer Latest breast cancer treatments Reorganisation of breast cancer services
Slide 9 - What to do if you feel a lump? Check the other breast Don’t panic! 9 out of 10 lumps are not cancerous Attend GP as soon as possible for review Referral to triple assessment specialist breast unit
Slide 10 - Triple Assessment Breast Unit Clinical exam Radiological assessment Pathological biopsy
Slide 11 - TABC Accuracy Gold standard of breast cancer diagnosis > 95% of symptomatic breast cancers diagnosed using TABC¹,²,³ 1) Merion Thomas J et al. Br Med J 1978; ii:1139 – 1141 2) Dixon JM et al. Br J Surg 1984; 71:593 – 596 3) Hermansen C et al. Cancer 1987; 60:1866 – 1871
Slide 12 - Breast Cancer Breast Cancer in Ireland If you find a lump… Treatments for breast cancer Latest breast cancer treatments Reorganisation of breast cancer services
Slide 13 - Treatments for breast cancer Surgery Chemotherapy Radiotherapy Hormonal therapy Biological therapy Neoadjuvant Versus Adjuvant
Slide 14 - Surgery Mastectomy Breast conservation Axillary lymph node clearance Sentinel Lymph node biopsy Breast Reconstruction DIEP, TRAM, LD
Slide 15 - Reconstructive Surgery
Slide 16 - Sentinel lymph node
Slide 17 - Breast Cancer Cell ER HER2 Tumour growth
Slide 18 - ER positive breast cancer 75% of Breast Cancers are ER positive 150,000 EU women are on “hormonal therapy” Tamoxifen, Arimidex, Femara, Aromasin Hormonal therapy
Slide 19 - Biological therapy HER2 positive breast cancer 25% breast cancers overexpress HER2 Herceptin, Tykerb (lapatinib)
Slide 20 - Clinical Trials International Institutional Establishing ‘best treatment’ Novel oncological drugs Molecular Research Audit & database review Beaumont Breast Cancer Research
Slide 21 - Breast Cancer Breast Cancer in Ireland If you find a lump… Treatments for breast cancer Latest breast cancer treatments Reorganisation of breast cancer services
Slide 22 - New diagnostic resources Gene expression studies Oncotype DX MammaPrint
Slide 23 - New surgical techniques Skin sparing mastectomy Only used when immediate reconstruction performed Oncoplastic Breast Reconstruction Immediate versus delayed
Slide 24 - New radiotherapy techniques Hypofractionated radiation Larger doses over fewer days Accelerated partial breast irradiation Intraoperative radiation therapy Intracavitary brachytherapy
Slide 25 - New Biological Treatments Targeting HER2 Neratinib Tovok Pertuzumab Anti-angiogenesis Bevacizumab Targeting EGFR Gefitinib Erlotinib Cetuximab Other Vitamin D Bisphosphonates
Slide 26 - The price tag of progress… Herceptin € 2,000 / month Lapatinib € 2,000 / month Bevacizumab € 3,000 / month Cetuximab € 3,400 / month
Slide 27 - Breast Cancer Breast Cancer in Ireland If you find a lump… Treatments for breast cancer Latest breast cancer treatments Reorganisation of breast cancer services
Slide 28 - Managed Cancer Control Networks& Cancer Centres
Slide 29 - Breast Cancer update
Slide 30 - Cancer Strategy
Slide 31 - Summary Lifetime risk of breast cancer 1 in 10 women Surgery & chemoradiotherapy the mainstay of treatment Hormonal and biological therapies increasing in efficacy, but costly Irish NCCP – 8 designated breast cancer centres
Slide 32 - Thank you