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Update on Breast Cancer

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Update on Breast Cancer PowerPoint Presentation

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Published on : Mar 14, 2014
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Slide 1 - Vida! Educational Series – Promoting Good HealthWelcome! - We will begin shortly If viewing by internet: for technical help: 520-626-0167 Please complete surveys:
Slide 2 - Update in Breast Cancer Ana Maria Lopez, MD, MPH, FACP Associate Dean, Outreach and Multicultural Affairs Professor of Medicine and Pathology Medical Director, Arizona Telemedicine Program
Slide 3 - Educational Objectives 1. Learn what is breast cancer 2. Discuss risks to breast cancer 3. Outline prevention measures for breast cancer
Slide 4 - What is breast cancer?
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Slide 9 - What causes breast cancer? Causes and risk factors
Slide 10 - Risk Factors Age: 95% in women 40yo + highest in 70-74 yo FH Personal history Genetic risk: BRCA 1/2, TP 53, ATM Nulliparous 1st full term pregnancy after 35 yo No lactation HRT Alcohol Overweight/obesity Physical inactivity
Slide 11 - 70% of breast cancers are in patients without identifiable risk factors
Slide 12 - Risk Calculators NCI/NSABP
Slide 13 - Hereditary Breast Cancer Risks 5-10% of all breast cancers Ashkenazi Jewish descent 3 or more 1st or 2nd degree relatives 1st degree relative with bilateral breast cancer 2 or more 1st or 2nd degree relatives with ovarian cancer Male breast cancer
Slide 14 - BRCA 1 and BRCA 2 Code for DNA repair Presence of gene, increases the risk of getting breast cancer up to 80% in her lifetime BRCA1 or BRCA2 mutations make up about half of all cases of inherited breast cancer associated with ovarian cancer and prostate cancer can be inherited either from the mother or the father.
Slide 15 - Other Inherited Genes TP53 gene codes for the tumor suppressor protein p53 Mutations cause Li-Fraumeni syndrome: associated with early onset breast cancer Ataxia Telangiectasia (ATM) gene Females with one defective copy of the ATM gene and one normal copy of the gene are at increased risk for breast cancer.
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Slide 23 - Prevention
Slide 24 - Prevention: saves us from the pain of being sick --Unknown
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Slide 26 - Prevention Studies Tamoxifen Raloxifen: STAR (Study of Tamoxifen and Raloxifene) Raloxifene is as effective as tamoxifen in reducing invasive but not nonivasive (DCIS) BC risk Both drugs reduce invasive BC risk by about 50% Raloxifene: 36% fewer uterine cancers, 29% fewer blood clots Both increase blood clots.
Slide 27 - Aspirin In an epidemiologic study, aspirin appeared to lower breast cancer risk Need prospective trial
Slide 28 - Vitamin D Helps with calcium absorption to maintain bone density In clinical trials
Slide 29 - Fat WINS Low fat diet (< 30%) 5Y FU: new breast cancers--9.8% low-fat diet; 12.4% standard diet (24% reduction) largest risk reduction – 42%--in ER negative tumors
Slide 30 - What about soy? Flax? Phytoestrogens? Eat what you like! Eat healthy! Do not change your diet drastically to include phytoestrogens. There may be safety concerns re: pharmaceutically concentrated soy products
Slide 31 - Lifestyle Maintain a healthy weight Decrease intake overall. Increase vegetables in specific (2/3 of plate) Increase activity: 3-4 hours of exercise per week Decrease alcohol intake
Slide 32 - Early Detection
Slide 33 - Computer-aided detection and diagnosis (CAD)
Slide 34 - Tomosynthesis (3D mammography)
Slide 35 - Treatment
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