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Slide 1 - BioMEMS Device Integration, Packaging and Control for BioMEMS Rubloff Research Group Accomplishments
Slide 2 - BioMEMS Device Integration, Packaging and Control for BioMEMS People involved Jung Jin Park, Xiaolong Luo, Theresa Valentine, Gary Rubloff Collaborations with Reza Ghodssi, Hyunmin Yi, Greg Payne, Bill Bentley Links Accomplishment Microfabricated SU8 on a Pyrex wafer defines the microchannel structure Patterned gold electrodes define the readily addressable assembly sites SU8-PDMS junction by pressure provides leak-tight and nonpermanent sealing Fluidic/electric ports provide transport and electric signal for biochemical assembly LabView-based control system coordinates liquid transport and electrodeposition Significance Integrated microfluidic system provides electric signal and optical access for biochemical assembly Nonpermanent sealing provides ex situ, post-process analysis Reusable packaging components Microfluidic Control System provides systematic operation process
Slide 3 - BioMEMS Device Integration, Packaging and Control for BioMEMS Publications X. L. Luo, A. T. Lewandowski, H. M. Yi, R. Ghodssi, G. F. Payne, W. E. Bentley and G. W. Rubloff, “Reproducible Assembly and Catalytic Activity of a Metabolic Pathway Enzyme in Reusable BioMEMS Devices”, Lab on a Chip, Submitted. J. J. Park, X. L. Luo, H. M. Yi, T. M. Valentine, G. F. Payne, W. E. Bentley, R. Ghodssi and G. W. Rubloff, “Chitosan-mediated in situ biomolecule assembly in completely packaged microfluidic devices”, Lab on a Chip, 2006, 6, 1315-1321. J. J. Park, T. M. Valentine, R. Ghodssi, and G. W. Rubloff, “Integrated Chip and Package Design for Surface-Controlled Bioreaction Processes with Robust, Reusable Fluidic Sealing“, Proceedings of MicroTAS 2005, 9th International Conference on Miniaturized Systems in Chemistry and Life Sciences (2005) Presentations J.J. Park, M.A. Powers, X. Luo, R. Ghodssi, and G.W. Rubloff, “BioMEMS Chip and Package Design for Surface-Controlled Bioreaction Processes”, American Vacuum Society 52nd International Symposium & Exhibition, Boston, MA, October 30-November 4, 2005. J. J. Park, T. M. Valentine, R. Ghodssi, and G. W. Rubloff, “Integrated Chip and Package Design for Surface-Controlled Bioreaction Processes with Robust, Reusable Fluidic Sealing“, Proceedings of MicroTAS 2005, 9th International Conference on Miniaturized Systems in Chemistry and Life Sciences (2005)
Slide 4 - Biopolymer-based BioMEMS BioMEMS refers to the application of microelectromechanical systems (MEMS) to biology. Current bioMEMS devices are either semiconductor-based or polymer-based, mostly PDMS. A biopolymer-based bioMEMS devices are created when chitosan is enlisted. The unique properties of aminopolysaccharide chitosan confer the bioMEMS device with special advantages such as reusability and low average-use cost.
Slide 5 - Drilled holes in 4” Pyrex Au deposition and patterning patterning SU8 microchannel Electrical I/O Fluidic I/O Pyrex Compression bolt Microchannel ( 500 mm) Pyrex Electrode (1 mm x 0.5 mm) Side wall (400 mm x 150 mm) Design Fabrication BioMEMS Device Design and Fabrication
Slide 6 - SU8 knife edge / PDMS gasket sealing Testing flow rate: ~ 50 ml/min Compression Sealing
Slide 7 - Features Non-permanent sealing Fluidic and electrical I/O Reusable packaging components Transparency for optical access Microfluidic Package Optical micrograph
Slide 8 - (a) BioMEMS Device and Control System