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The Eight Phases of Inflammation

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The Eight Phases of Inflammation PowerPoint Presentation

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Published on : Aug 07, 2014
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Slide 1 - The Eight Phases of Inflammation
Slide 2 - Injury Utrastructural Changes Metabolic (Hypoxic) Changes Activation of Chemical Mediators Hemodynamic Changes Permeability Changes Leukocyte Migration Phagocytosis The Eight Phases of Inflammation
Slide 3 - Phases of Inflammation Injury - any event that impairs tissue structure Trauma (most sports injuries) macrotrauma (impact, contact) microtrauma (overuse, friction)
Slide 4 - Phases of Inflammation Ultrastructural Changes disruption of the cell membrane contents of cell spill into extracellular spaces caused by trauma hypoxia
Slide 5 - Phases of Inflammation Metabolic (Hypoxic) Changes cells become deprived of oxygen (secondary hypoxic injury) sodium pump fails sodium increases in cell cell membrane disruption contents spill out
Slide 6 - Phases of Inflammation Activation of Chemical Mediators Chemical mediators (histamine, bradykinin) spill out of the cell Chemical mediators notify body that cells have been damaged mobilize the body=s resources to handle the situation modify and regulate the rest of the inflammatory response
Slide 7 - Phases of Inflammation Hemodynamic Changes arteries dilate enhancing blood flow inactive capillaries and venules open total blood flow increases, rate of flow decreases leukocytes fall out of stream line and adhere to vessel wall
Slide 8 - Phases of Inflammation Permeability Changes sizable gaps develop in the vessel walls. leukocytes escape to injury site
Slide 9 - Leukocyte Migration leukocytes migrate in concentration-limited fashion more chemical mediators, more leukocytes 2 types of leukocytes neutrophils travel fast, arrive first temporary first line of defense live 7 hours macrophages second line of defense live for months Phases of Inflammation
Slide 10 - Phagocytosis process of digesting cellular debris into pieces small enough to be removed by the lymph vessels. Phases of Inflammation