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Targeting Thyroid Cancer PowerPoint Presentation

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On : Feb 24, 2014

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  • Slide 1 - Targeting Thyroid Cancer
  • Slide 2 - Program Goal
  • Slide 3 - Thyroid Cancer Newly Detected 2013 (n=60,220)
  • Slide 4 - Follicular Cell Thyroid Cancer Deaths 2013 (n = 1850)
  • Slide 5 - Familial Syndromes
  • Slide 6 - Thyroid Cancer Treatment “Pyramid”
  • Slide 7 - Risk Stratification
  • Slide 8 - ppt slide no 8 content not found
  • Slide 9 - ppt slide no 9 content not found
  • Slide 10 - RAI-Refractory Disease
  • Slide 11 - Doxorubicin: Single-agent Activity
  • Slide 12 - Doxorubicin +/- Cisplatin
  • Slide 13 - Doxorubicin +/- Cisplatin: Results
  • Slide 14 - ppt slide no 14 content not found
  • Slide 15 - Targets in Thyroid Cancer
  • Slide 16 - VEGF and Thyroid Cancer
  • Slide 17 - Sorafenib
  • Slide 18 - Sorafenib University of Pennsylvania
  • Slide 19 - Sorafenib Results University of Pennsylvania
  • Slide 20 - Sorafenib Ohio State
  • Slide 21 - Sorafenib Results Ohio State
  • Slide 22 - Sorafenib Response Rates Ohio State vs Penn
  • Slide 23 - DECISION Study
  • Slide 24 - DECISION Study Results
  • Slide 25 - DECISION Study Response Rates
  • Slide 26 - Lenvatinib (E7080) Background
  • Slide 27 - Lenvatinib Response Rate
  • Slide 28 - Differentiated Thyroid Cancers Phase 2 Studies -- Multitargeted TKIs
  • Slide 29 - Summary of Angiogenesis Inhibition
  • Slide 30 - Genetic Alterations in Thyroid Cancer
  • Slide 31 - Concordance of Genetic Alterations in MAPK but Not PI3K Pathway Oncogenes
  • Slide 32 - Selumetinib (AZD6244)
  • Slide 33 - Selumetinib Response Rate
  • Slide 34 - ppt slide no 34 content not found
  • Slide 35 - Impact of Selumetinib on 124I Incorporation
  • Slide 36 - ppt slide no 36 content not found
  • Slide 37 - Responses for RAI-Treated Patients
  • Slide 38 - BRAF
  • Slide 39 - Vemurafenib
  • Slide 40 - Vemurafenib Response Rate
  • Slide 41 - Current Studies for BRAF Mutant Thyroid Cancer
  • Slide 42 - Summary of BRAF and MEK targets
  • Slide 43 - Medullary Thyroid Cancer
  • Slide 44 - Presentations of MCT
  • Slide 45 - MTC: Hereditary vs Sporadic?
  • Slide 46 - Hereditary MTC Until Proven Otherwise
  • Slide 47 - Sporadic MTC Frequency of RET Mutations
  • Slide 48 - Vandetanib (ZD6474)
  • Slide 49 - Vandetanib: Randomized Phase 3 Trial
  • Slide 50 - Vandetanib: PFS
  • Slide 51 - Vandetanib: Objective Tumor Assessments
  • Slide 52 - Cabozantinib (XL184)
  • Slide 53 - Cabozantinib: Phase 3 Study Design (EXAM)
  • Slide 54 - Cabozantinib: PFS
  • Slide 55 - Summary of Medullary Thyroid Cancer
  • Slide 56 - Abbreviations
  • Slide 57 - Abbreviations (cont)
  • Slide 58 - Abbreviations (cont)
  • Slide 59 - References
  • Slide 60 - References (cont)
  • Slide 61 - References (cont)
  • Slide 62 - References (cont)
  • Slide 63 - References (cont)
  • Slide 64 - References (cont)
  • Slide 65 - References (cont)

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