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Slide 1 - Yale SPORE in Skin Cancer Directors: Ruth Halaban, PhD Mario Sznol, MD Robert Tigelaar, MD Funded by: National Institutes of Health The Roslyn and Jeremy Meyer funds Yale Dermatology Department
Slide 2 - Yale SPORE in Skin Cancer Directors: Ruth Halaban, PhD Mario Sznol, MD Robert Tigelaar, MD Funded by: National Institutes of Health The Roslyn and Jeremy Meyer funds Yale Dermatology Department Milstein Meyer Center for Melanoma Research Jeremy Meyer and Roslyn Milstein Meyer “Couple with a Cause” Gift of $2 Million/year renewable for additional 4 years
Slide 3 - Yale SPORE in Skin Cancer Directors: Ruth Halaban, PhD Mario Sznol, MD Robert Tigelaar, MD Funded by: National Institutes of Health The Roslyn and Jeremy Meyer funds Yale Dermatology Department Milstein Meyer Center for Melanoma Research Jeremy Meyer and Roslyn Milstein Meyer “Couple with a Cause” Gift of $2 Million/year renewable for additional 4 years The SPORE Program Translation Research in Skin Cancer Melanomas Basal Cell Carcinoma
Slide 4 - Yale SPORE in Skin Cancer Directors: Ruth Halaban, PhD Mario Sznol, MD Robert Tigelaar, MD Funded by: National Institutes of Health The Roslyn and Jeremy Meyer funds Yale Dermatology Department Milstein Meyer Center for Melanoma Research Jeremy Meyer and Roslyn Milstein Meyer “Couple with a Cause” Gift of $2 Million/year renewable for additional 4 years The SPORE Program Translation Research in Skin Cancer Melanomas Basal Cell Carcinoma The SPORE Program Three cores that support SPORE activities Four translational projects Developmental Research Projects Career Development Projects
Slide 5 - Yale SPORE in Skin Cancer Directors: Ruth Halaban, PhD Mario Sznol, MD Robert Tigelaar, MD Funded by: National Institutes of Health The Roslyn and Jeremy Meyer funds Yale Dermatology Department Milstein Meyer Center for Melanoma Research Jeremy Meyer and Roslyn Milstein Meyer “Couple with a Cause” Gift of $2 Million/year renewable for additional 4 years The SPORE Program Translation Research in Skin Cancer Melanomas Basal Cell Carcinoma The SPORE Program Three cores that support SPORE activities Four translational projects Developmental Research Projects Career Development Projects Translational Research Team SPORE Expansion Number of Investigators 0 0 ( S u b m i s s i o n ) Y e a r 1 Y e a r 2 1 0 2 0 3 0 4 0 5 0 6 0 7 0 Roslyn Milstein Meyer Susan Cambria Robin Bessin Robert Heffernan
Slide 6 - Yale SPORE in Skin Cancer Directors: Ruth Halaban, PhD Mario Sznol, MD Robert Tigelaar, MD Funded by: National Institutes of Health The Roslyn and Jeremy Meyer funds Yale Dermatology Department Milstein Meyer Center for Melanoma Research Jeremy Meyer and Roslyn Milstein Meyer “Couple with a Cause” Gift of $2 Million/year renewable for additional 4 years The SPORE Program Translation Research in Skin Cancer Melanomas Basal Cell Carcinoma The SPORE Program Three cores that support SPORE activities Four translational projects Developmental Research Projects Career Development Projects Translational Research Team SPORE Expansion Number of Investigators 0 0 ( S u b m i s s i o n ) Y e a r 1 Y e a r 2 1 0 2 0 3 0 4 0 5 0 6 0 7 0 Roslyn Milstein Meyer Susan Cambria Robin Bessin Robert Heffernan Translational Research Team 1 Dermatology 2 YCCC/Oncology 3 Pathology 4 Surgery 5 Genetics 6 Immunobiology 7 Epidemiology 8 Chemical & Biomedical Engineering 9 Therapeutic Radiology 10 Laboratory Medicine and Genetics Molecular, Cellular, and Developmental Biology Cell Biology, New York University, NY
Slide 7 - Yale SPORE in Skin Cancer Directors: Ruth Halaban, PhD Mario Sznol, MD Robert Tigelaar, MD Funded by: National Institutes of Health The Roslyn and Jeremy Meyer funds Yale Dermatology Department Milstein Meyer Center for Melanoma Research Jeremy Meyer and Roslyn Milstein Meyer “Couple with a Cause” Gift of $2 Million/year renewable for additional 4 years The SPORE Program Translation Research in Skin Cancer Melanomas Basal Cell Carcinoma The SPORE Program Three cores that support SPORE activities Four translational projects Developmental Research Projects Career Development Projects Translational Research Team SPORE Expansion Number of Investigators 0 0 ( S u b m i s s i o n ) Y e a r 1 Y e a r 2 1 0 2 0 3 0 4 0 5 0 6 0 7 0 Roslyn Milstein Meyer Susan Cambria Robin Bessin Robert Heffernan Translational Research Team 1 Dermatology 2 YCCC/Oncology 3 Pathology 4 Surgery 5 Genetics 6 Immunobiology 7 Epidemiology 8 Chemical & Biomedical Engineering 9 Therapeutic Radiology 10 Laboratory Medicine and Genetics Molecular, Cellular, and Developmental Biology Cell Biology, New York University, NY “The Melanoma Landscape” Critical changes that drive melanomas Immunobiology of melanomas The causes for drug resistance New targets for therapy, single and combination Markers for prognosis and therapy Comprehensive understanding of:
Slide 8 - Yale SPORE in Skin Cancer Directors: Ruth Halaban, PhD Mario Sznol, MD Robert Tigelaar, MD Funded by: National Institutes of Health The Roslyn and Jeremy Meyer funds Yale Dermatology Department Milstein Meyer Center for Melanoma Research Jeremy Meyer and Roslyn Milstein Meyer “Couple with a Cause” Gift of $2 Million/year renewable for additional 4 years The SPORE Program Translation Research in Skin Cancer Melanomas Basal Cell Carcinoma The SPORE Program Three cores that support SPORE activities Four translational projects Developmental Research Projects Career Development Projects Translational Research Team SPORE Expansion Number of Investigators 0 0 ( S u b m i s s i o n ) Y e a r 1 Y e a r 2 1 0 2 0 3 0 4 0 5 0 6 0 7 0 Roslyn Milstein Meyer Susan Cambria Robin Bessin Robert Heffernan Translational Research Team 1 Dermatology 2 YCCC/Oncology 3 Pathology 4 Surgery 5 Genetics 6 Immunobiology 7 Epidemiology 8 Chemical & Biomedical Engineering 9 Therapeutic Radiology 10 Laboratory Medicine and Genetics Molecular, Cellular, and Developmental Biology Cell Biology, New York University, NY “The Melanoma Landscape” Critical changes that drive melanomas Immunobiology of melanomas The causes for drug resistance New targets for therapy, single and combination Markers for prognosis and therapy Comprehensive understanding of: SPORE Biospecimen Bank Normal skin and cells Tumors Tumor cells Blood from healthy individuals Blood from patients Specimen Tracking and Annotation caTissue
Slide 9 - Yale SPORE in Skin Cancer Directors: Ruth Halaban, PhD Mario Sznol, MD Robert Tigelaar, MD Funded by: National Institutes of Health The Roslyn and Jeremy Meyer funds Yale Dermatology Department Milstein Meyer Center for Melanoma Research Jeremy Meyer and Roslyn Milstein Meyer “Couple with a Cause” Gift of $2 Million/year renewable for additional 4 years The SPORE Program Translation Research in Skin Cancer Melanomas Basal Cell Carcinoma The SPORE Program Three cores that support SPORE activities Four translational projects Developmental Research Projects Career Development Projects Translational Research Team SPORE Expansion Number of Investigators 0 0 ( S u b m i s s i o n ) Y e a r 1 Y e a r 2 1 0 2 0 3 0 4 0 5 0 6 0 7 0 Roslyn Milstein Meyer Susan Cambria Robin Bessin Robert Heffernan Translational Research Team 1 Dermatology 2 YCCC/Oncology 3 Pathology 4 Surgery 5 Genetics 6 Immunobiology 7 Epidemiology 8 Chemical & Biomedical Engineering 9 Therapeutic Radiology 10 Laboratory Medicine and Genetics Molecular, Cellular, and Developmental Biology Cell Biology, New York University, NY “The Melanoma Landscape” Critical changes that drive melanomas Immunobiology of melanomas The causes for drug resistance New targets for therapy, single and combination Markers for prognosis and therapy Comprehensive understanding of: SPORE Biospecimen Bank Normal skin and cells Tumors Tumor cells Blood from healthy individuals Blood from patients Specimen Tracking and Annotation caTissue Specimens’ Collection in the Tissue Bank Total Number of Specimens 0 100 200 300 400 500 600 700 Submission Year 1 Year 2 Current Year 2 1/2
Slide 10 - Yale SPORE in Skin Cancer Directors: Ruth Halaban, PhD Mario Sznol, MD Robert Tigelaar, MD Funded by: National Institutes of Health The Roslyn and Jeremy Meyer funds Yale Dermatology Department Milstein Meyer Center for Melanoma Research Jeremy Meyer and Roslyn Milstein Meyer “Couple with a Cause” Gift of $2 Million/year renewable for additional 4 years The SPORE Program Translation Research in Skin Cancer Melanomas Basal Cell Carcinoma The SPORE Program Three cores that support SPORE activities Four translational projects Developmental Research Projects Career Development Projects Translational Research Team SPORE Expansion Number of Investigators 0 0 ( S u b m i s s i o n ) Y e a r 1 Y e a r 2 1 0 2 0 3 0 4 0 5 0 6 0 7 0 Roslyn Milstein Meyer Susan Cambria Robin Bessin Robert Heffernan Translational Research Team 1 Dermatology 2 YCCC/Oncology 3 Pathology 4 Surgery 5 Genetics 6 Immunobiology 7 Epidemiology 8 Chemical & Biomedical Engineering 9 Therapeutic Radiology 10 Laboratory Medicine and Genetics Molecular, Cellular, and Developmental Biology Cell Biology, New York University, NY “The Melanoma Landscape” Critical changes that drive melanomas Immunobiology of melanomas The causes for drug resistance New targets for therapy, single and combination Markers for prognosis and therapy Comprehensive understanding of: SPORE Biospecimen Bank Normal skin and cells Tumors Tumor cells Blood from healthy individuals Blood from patients Specimen Tracking and Annotation caTissue Specimens’ Collection in the Tissue Bank Total Number of Specimens 0 100 200 300 400 500 600 700 Submission Year 1 Year 2 Current Year 2 1/2 Serological Profiling of Melanoma Patients Weeks of Treatment Marker B Marker A Concentration (ng/ml)
Slide 11 - Yale SPORE in Skin Cancer Directors: Ruth Halaban, PhD Mario Sznol, MD Robert Tigelaar, MD Funded by: National Institutes of Health The Roslyn and Jeremy Meyer funds Yale Dermatology Department Milstein Meyer Center for Melanoma Research Jeremy Meyer and Roslyn Milstein Meyer “Couple with a Cause” Gift of $2 Million/year renewable for additional 4 years The SPORE Program Translation Research in Skin Cancer Melanomas Basal Cell Carcinoma The SPORE Program Three cores that support SPORE activities Four translational projects Developmental Research Projects Career Development Projects Translational Research Team SPORE Expansion Number of Investigators 0 0 ( S u b m i s s i o n ) Y e a r 1 Y e a r 2 1 0 2 0 3 0 4 0 5 0 6 0 7 0 Roslyn Milstein Meyer Susan Cambria Robin Bessin Robert Heffernan Translational Research Team 1 Dermatology 2 YCCC/Oncology 3 Pathology 4 Surgery 5 Genetics 6 Immunobiology 7 Epidemiology 8 Chemical & Biomedical Engineering 9 Therapeutic Radiology 10 Laboratory Medicine and Genetics Molecular, Cellular, and Developmental Biology Cell Biology, New York University, NY “The Melanoma Landscape” Critical changes that drive melanomas Immunobiology of melanomas The causes for drug resistance New targets for therapy, single and combination Markers for prognosis and therapy Comprehensive understanding of: SPORE Biospecimen Bank Normal skin and cells Tumors Tumor cells Blood from healthy individuals Blood from patients Specimen Tracking and Annotation caTissue Specimens’ Collection in the Tissue Bank Total Number of Specimens 0 100 200 300 400 500 600 700 Submission Year 1 Year 2 Current Year 2 1/2 Serological Profiling of Melanoma Patients Weeks of Treatment Marker B Marker A Concentration (ng/ml) Global “Omics” Test Genetic and epigenetic variations Mutations Gene expression Kinases and signal transducers MicroRNA
Slide 12 - Yale SPORE in Skin Cancer Directors: Ruth Halaban, PhD Mario Sznol, MD Robert Tigelaar, MD Funded by: National Institutes of Health The Roslyn and Jeremy Meyer funds Yale Dermatology Department Milstein Meyer Center for Melanoma Research Jeremy Meyer and Roslyn Milstein Meyer “Couple with a Cause” Gift of $2 Million/year renewable for additional 4 years The SPORE Program Translation Research in Skin Cancer Melanomas Basal Cell Carcinoma The SPORE Program Three cores that support SPORE activities Four translational projects Developmental Research Projects Career Development Projects Translational Research Team SPORE Expansion Number of Investigators 0 0 ( S u b m i s s i o n ) Y e a r 1 Y e a r 2 1 0 2 0 3 0 4 0 5 0 6 0 7 0 Roslyn Milstein Meyer Susan Cambria Robin Bessin Robert Heffernan Translational Research Team 1 Dermatology 2 YCCC/Oncology 3 Pathology 4 Surgery 5 Genetics 6 Immunobiology 7 Epidemiology 8 Chemical & Biomedical Engineering 9 Therapeutic Radiology 10 Laboratory Medicine and Genetics Molecular, Cellular, and Developmental Biology Cell Biology, New York University, NY “The Melanoma Landscape” Critical changes that drive melanomas Immunobiology of melanomas The causes for drug resistance New targets for therapy, single and combination Markers for prognosis and therapy Comprehensive understanding of: SPORE Biospecimen Bank Normal skin and cells Tumors Tumor cells Blood from healthy individuals Blood from patients Specimen Tracking and Annotation caTissue Specimens’ Collection in the Tissue Bank Total Number of Specimens 0 100 200 300 400 500 600 700 Submission Year 1 Year 2 Current Year 2 1/2 Serological Profiling of Melanoma Patients Weeks of Treatment Marker B Marker A Concentration (ng/ml) Global “Omics” Test Genetic and epigenetic variations Mutations Gene expression Kinases and signal transducers MicroRNA Global Epigenetic Differences Between Normal and Malignant Cells Melanoma Normal Gain Loss
Slide 13 - Yale SPORE in Skin Cancer Directors: Ruth Halaban, PhD Mario Sznol, MD Robert Tigelaar, MD Funded by: National Institutes of Health The Roslyn and Jeremy Meyer funds Yale Dermatology Department Milstein Meyer Center for Melanoma Research Jeremy Meyer and Roslyn Milstein Meyer “Couple with a Cause” Gift of $2 Million/year renewable for additional 4 years The SPORE Program Translation Research in Skin Cancer Melanomas Basal Cell Carcinoma The SPORE Program Three cores that support SPORE activities Four translational projects Developmental Research Projects Career Development Projects Translational Research Team SPORE Expansion Number of Investigators 0 0 ( S u b m i s s i o n ) Y e a r 1 Y e a r 2 1 0 2 0 3 0 4 0 5 0 6 0 7 0 Roslyn Milstein Meyer Susan Cambria Robin Bessin Robert Heffernan Translational Research Team 1 Dermatology 2 YCCC/Oncology 3 Pathology 4 Surgery 5 Genetics 6 Immunobiology 7 Epidemiology 8 Chemical & Biomedical Engineering 9 Therapeutic Radiology 10 Laboratory Medicine and Genetics Molecular, Cellular, and Developmental Biology Cell Biology, New York University, NY “The Melanoma Landscape” Critical changes that drive melanomas Immunobiology of melanomas The causes for drug resistance New targets for therapy, single and combination Markers for prognosis and therapy Comprehensive understanding of: SPORE Biospecimen Bank Normal skin and cells Tumors Tumor cells Blood from healthy individuals Blood from patients Specimen Tracking and Annotation caTissue Specimens’ Collection in the Tissue Bank Total Number of Specimens 0 100 200 300 400 500 600 700 Submission Year 1 Year 2 Current Year 2 1/2 Serological Profiling of Melanoma Patients Weeks of Treatment Marker B Marker A Concentration (ng/ml) Global “Omics” Test Genetic and epigenetic variations Mutations Gene expression Kinases and signal transducers MicroRNA Global Epigenetic Differences Between Normal and Malignant Cells Melanoma Normal Gain Loss Differences in Gene Expression Between Normal and Malignant Cells Melanoma Normal Loss Gain
Slide 14 - Yale SPORE in Skin Cancer Directors: Ruth Halaban, PhD Mario Sznol, MD Robert Tigelaar, MD Funded by: National Institutes of Health The Roslyn and Jeremy Meyer funds Yale Dermatology Department Milstein Meyer Center for Melanoma Research Jeremy Meyer and Roslyn Milstein Meyer “Couple with a Cause” Gift of $2 Million/year renewable for additional 4 years The SPORE Program Translation Research in Skin Cancer Melanomas Basal Cell Carcinoma The SPORE Program Three cores that support SPORE activities Four translational projects Developmental Research Projects Career Development Projects Translational Research Team SPORE Expansion Number of Investigators 0 0 ( S u b m i s s i o n ) Y e a r 1 Y e a r 2 1 0 2 0 3 0 4 0 5 0 6 0 7 0 Roslyn Milstein Meyer Susan Cambria Robin Bessin Robert Heffernan Translational Research Team 1 Dermatology 2 YCCC/Oncology 3 Pathology 4 Surgery 5 Genetics 6 Immunobiology 7 Epidemiology 8 Chemical & Biomedical Engineering 9 Therapeutic Radiology 10 Laboratory Medicine and Genetics Molecular, Cellular, and Developmental Biology Cell Biology, New York University, NY “The Melanoma Landscape” Critical changes that drive melanomas Immunobiology of melanomas The causes for drug resistance New targets for therapy, single and combination Markers for prognosis and therapy Comprehensive understanding of: SPORE Biospecimen Bank Normal skin and cells Tumors Tumor cells Blood from healthy individuals Blood from patients Specimen Tracking and Annotation caTissue Specimens’ Collection in the Tissue Bank Total Number of Specimens 0 100 200 300 400 500 600 700 Submission Year 1 Year 2 Current Year 2 1/2 Serological Profiling of Melanoma Patients Weeks of Treatment Marker B Marker A Concentration (ng/ml) Global “Omics” Test Genetic and epigenetic variations Mutations Gene expression Kinases and signal transducers MicroRNA Global Epigenetic Differences Between Normal and Malignant Cells Melanoma Normal Gain Loss Differences in Gene Expression Between Normal and Malignant Cells Melanoma Normal Loss Gain Interactions Between the SPORE and Clinicians Help in testing for mutations in tumors for targeted therapy For example: selection of patients to therapy with PLX4032 (Plexxikon Inc.) and Imatinib (Gleevec, Novartis Pharmaceuticals), activated BRAF and KIT inhibitors, respectively.
Slide 15 - Yale SPORE in Skin Cancer Directors: Ruth Halaban, PhD Mario Sznol, MD Robert Tigelaar, MD Funded by: National Institutes of Health The Roslyn and Jeremy Meyer funds Yale Dermatology Department Milstein Meyer Center for Melanoma Research Jeremy Meyer and Roslyn Milstein Meyer “Couple with a Cause” Gift of $2 Million/year renewable for additional 4 years The SPORE Program Translation Research in Skin Cancer Melanomas Basal Cell Carcinoma The SPORE Program Three cores that support SPORE activities Four translational projects Developmental Research Projects Career Development Projects Translational Research Team SPORE Expansion Number of Investigators 0 0 ( S u b m i s s i o n ) Y e a r 1 Y e a r 2 1 0 2 0 3 0 4 0 5 0 6 0 7 0 Roslyn Milstein Meyer Susan Cambria Robin Bessin Robert Heffernan Translational Research Team 1 Dermatology 2 YCCC/Oncology 3 Pathology 4 Surgery 5 Genetics 6 Immunobiology 7 Epidemiology 8 Chemical & Biomedical Engineering 9 Therapeutic Radiology 10 Laboratory Medicine and Genetics Molecular, Cellular, and Developmental Biology Cell Biology, New York University, NY “The Melanoma Landscape” Critical changes that drive melanomas Immunobiology of melanomas The causes for drug resistance New targets for therapy, single and combination Markers for prognosis and therapy Comprehensive understanding of: SPORE Biospecimen Bank Normal skin and cells Tumors Tumor cells Blood from healthy individuals Blood from patients Specimen Tracking and Annotation caTissue Specimens’ Collection in the Tissue Bank Total Number of Specimens 0 100 200 300 400 500 600 700 Submission Year 1 Year 2 Current Year 2 1/2 Serological Profiling of Melanoma Patients Weeks of Treatment Marker B Marker A Concentration (ng/ml) Global “Omics” Test Genetic and epigenetic variations Mutations Gene expression Kinases and signal transducers MicroRNA Global Epigenetic Differences Between Normal and Malignant Cells Melanoma Normal Gain Loss Differences in Gene Expression Between Normal and Malignant Cells Melanoma Normal Loss Gain Interactions Between the SPORE and Clinicians Help in testing for mutations in tumors for targeted therapy For example: selection of patients to therapy with PLX4032 (Plexxikon Inc.) and Imatinib (Gleevec, Novartis Pharmaceuticals), activated BRAF and KIT inhibitors, respectively. Educational Activities Invited speakers Research in Progress meetings Workshop for all SPOREs in Skin Cancer Outreach with patient advocates
Slide 16 - Yale SPORE in Skin Cancer Directors: Ruth Halaban, PhD Mario Sznol, MD Robert Tigelaar, MD Funded by: National Institutes of Health The Roslyn and Jeremy Meyer funds Yale Dermatology Department Milstein Meyer Center for Melanoma Research Jeremy Meyer and Roslyn Milstein Meyer “Couple with a Cause” Gift of $2 Million/year renewable for additional 4 years The SPORE Program Translation Research in Skin Cancer Melanomas Basal Cell Carcinoma The SPORE Program Three cores that support SPORE activities Four translational projects Developmental Research Projects Career Development Projects Translational Research Team SPORE Expansion Number of Investigators 0 0 ( S u b m i s s i o n ) Y e a r 1 Y e a r 2 1 0 2 0 3 0 4 0 5 0 6 0 7 0 Roslyn Milstein Meyer Susan Cambria Robin Bessin Robert Heffernan Translational Research Team 1 Dermatology 2 YCCC/Oncology 3 Pathology 4 Surgery 5 Genetics 6 Immunobiology 7 Epidemiology 8 Chemical & Biomedical Engineering 9 Therapeutic Radiology 10 Laboratory Medicine and Genetics Molecular, Cellular, and Developmental Biology Cell Biology, New York University, NY “The Melanoma Landscape” Critical changes that drive melanomas Immunobiology of melanomas The causes for drug resistance New targets for therapy, single and combination Markers for prognosis and therapy Comprehensive understanding of: SPORE Biospecimen Bank Normal skin and cells Tumors Tumor cells Blood from healthy individuals Blood from patients Specimen Tracking and Annotation caTissue Specimens’ Collection in the Tissue Bank Total Number of Specimens 0 100 200 300 400 500 600 700 Submission Year 1 Year 2 Current Year 2 1/2 Serological Profiling of Melanoma Patients Weeks of Treatment Marker B Marker A Concentration (ng/ml) Global “Omics” Test Genetic and epigenetic variations Mutations Gene expression Kinases and signal transducers MicroRNA Global Epigenetic Differences Between Normal and Malignant Cells Melanoma Normal Gain Loss Differences in Gene Expression Between Normal and Malignant Cells Melanoma Normal Loss Gain Interactions Between the SPORE and Clinicians Help in testing for mutations in tumors for targeted therapy For example: selection of patients to therapy with PLX4032 (Plexxikon Inc.) and Imatinib (Gleevec, Novartis Pharmaceuticals), activated BRAF and KIT inhibitors, respectively. Educational Activities Invited speakers Research in Progress meetings Workshop for all SPOREs in Skin Cancer Outreach with patient advocates Best-Case Scenario Mutations Activated targets Drug response Identify best therapy Tumor excised Draw blood Comprehensive analyses: Which therapy? Results Yes, this is the best for you