X

Download Phage-Bacteria Interactions PowerPoint Presentation


Login   OR  Register
X

Share page



  Preview

               
Home / Health & Wellness / Health & Wellness Presentations / Phage-Bacteria Interactions PowerPoint Presentation

Phage-Bacteria Interactions PowerPoint Presentation

slidesfinder By : slidesfinder

On : Mar 14, 2014

facebook   twitter   google plus  
In : Health & Wellness

Embed :
542
views

0
downloads
Login / Signup - with account for


  • → Make favorite
  • → Flag as inappropriate
  • → Download Presentation
  • → Share Presentation
  • Slide 1 - Biologic Antimicrobial Countermeasures “The enemy of my enemy is my friend*” Devon Byrd DTRA/ASX * usual caveats apply…
  • Slide 2 - Overview Bacteriophage are viruses that specifically destroy bacteria They use tricks shared by bacteria that kill other bacteria Most higher organisms have ways to kill bacteria These mechanisms are discoverable and exploitable In general, very efficient and man portable
  • Slide 3 - DECON Direct Action Biologic Countermeasures Cut Across Agent Defeat Missions DISRUPT DEFEAT DESTROY
  • Slide 4 - Bacteriophage (or phage for short)kill bacteria
  • Slide 5 - Generic Bacteriophage Structure
  • Slide 6 - Lytic Phage Replication
  • Slide 7 - Lysis of bacterial cells by phage (courtesy of Ry Young, TAMU)
  • Slide 8 - As lytic phage propagate, bacteria are destroyed
  • Slide 9 - Bacteriophage target many aspects of host microbial metabolism– Can be independently and/or synergistically exploited Phage produce products that disrupt the following bacterial systems: Genome integrity DNA replication Gene expression Protein synthesis Cellular integrity
  • Slide 10 - Phage are a paradigm for biologically-based antimicrobial countermeasures Bacteria have been in a molecular arms race for billions of years They have thoroughly worked out the best ways to kill each other… …as have other organisms (innate immunity) Very rich area for antimicrobial countermeasure R&D and acquisition
  • Slide 11 - Enzymatic Lysozymes B-glucosidases Nucleases Proteases Non-enzymatic Very effective on microbes (bacteria, viruses, fungi, etc.) Some evidence effective on spores Probably not useful for toxins Bacteriocins- produced by bacteria Antimicrobial peptides (AMPs)- produced by higher organisms Categories of antimicrobial proteins } Bugs Toxins and spores
  • Slide 12 - Examples of anti microbial agents that are produced by bacteria Anti sigma factors Inactivate bacterial transcription factors Toxin/antitoxin systems Disrupt various metabolic components Autolysins Programmed cell death Bacteriocins Cell lysis Replication Protein synthesis Gene expression
  • Slide 13 - Interaction of MccJ25 with RNAP secondary channel: a cork in the bottle
  • Slide 14 - Non-bacterial Sources Cecropins Thanatin Androctonin Defensins Magainins Bombinins Citropins Arthropods Amphibians Fish Pardaxin Parasin Hepcidin Nematodes ASABF (Ascaris suum antibacterial factor)
  • Slide 15 - Locations GSL Amazon Crimea Azov Sea Rift Valley Baikal Region
  • Slide 16 - Bio-prospecting Go somewhere (hi/low, hot/cold, wet/dry… it doesn’t matter- something will live there) Acquire indigenous knowledge (if possible) Recover specimens from various environments (soil, water, bugs, worms…) RTB specimens Analyze for useful properties/products
  • Slide 17 - Potency of selected AMPs *NOTE: values are extrapolated from reported data
  • Slide 18 - Phage Peptides Tend to be specific for a given target agent Need specific knowledge of target in order to deliver appropriate phage …or… Need to carry all possible phage for all possible target organisms No synergy when combined Essentially zero weight More generic- a properly selected peptide will be effective against a fairly wide range of bacteria Exhibit synergistic effects when combined- dramatic increase in potency and target range Extremely light weight Generally heat and desiccation stable Phage and peptides can be combined for maximum effect
  • Slide 19 - Selected Web Resources for antimicrobial peptides http://aps.unmc.edu/AP/main.php http://www.bbcm.units.it/~tossi/pag1.htm http://oma.terkko.helsinki.fi:8080/~SAPD/
  • Slide 20 - Conclusions Funding for mission-oriented, biologically-based antimicrobial/antitoxin R & D is needed Explore synergistic effects using mixed agent defeat components Work with subject matter experts to develop and optimize CONOPS Bring back specimens
ECG Heart Beat Free PowerPoint Template

ECG Heart Beat

Views : 1646

Back to School Free PowerPoint Template

Back to School

Views : 506

Yoga Meditation Free PowerPoint Template

Yoga Meditation

Views : 754

Morning Running Free PowerPoint Template

Morning Running

Views : 771

AI Free PowerPoint Template

AI

Views : 660

Wedding Cake Free PowerPoint Template

Wedding Cake

Views : 805

Dentist Free PowerPoint Template

Dentist

Views : 376

Butterfly Free PowerPoint Template

Butterfly

Views : 642

Stop Aids Free PowerPoint Template

Stop Aids

Views : 527

Drone Free PowerPoint Template

Drone

Views : 4100

Global Warming Pollution Free PowerPoint Template

Global Warming Pollution

Views : 873

Autumn Free PowerPoint Template

Autumn

Views : 563

Global Warming Free PowerPoint Template

Global Warming

Views : 550

Agriculture Free PowerPoint Template

Agriculture

Views : 904

Running Track Free PowerPoint Template

Running Track

Views : 426

Burger Free PowerPoint Template

Burger

Views : 558

Photography Free PowerPoint Template

Photography

Views : 448

Heart Free PowerPoint Template

Heart

Views : 484

Vegetables Free PowerPoint Template

Vegetables

Views : 506

Gerbera Free PowerPoint Template

Gerbera

Views : 336

Description : Available Phage-Bacteria Interactions powerpoint presentation for free download which is uploaded by honey an active user in belonging ppt presentation Health & Wellness category.

Tags : Phage-Bacteria Interactions

Shortcode : Get Shareable link