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Molecular Cell Biology PowerPoint Presentation

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Published on : Feb 10, 2014
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Slide 1 - Course in Molecular Biology Leuven, October – November 2002 Program Basics of molecular biology Transcription Translation Regulatory pathways DNA and diseases Biotechnology
Slide 2 - Lesson 1: Basics of molecular biology I. The Cell’s Organization II. Cell Cycle and Cell Division III. Cellular Molecules IV. The Genetic Dogma
Slide 3 - The Cell’s Organization
Slide 4 - All organisms: 1 or more cells
Slide 5 - The animal cell
Slide 6 - A plant cell
Slide 7 - A bacterium
Slide 8 - The Main Functions of the Membrane-bounded Compartments of a Eukaryotic Cell
Slide 9 - Compartimentation of the eukaryote cell: various organelles
Slide 10 - Cell nucleus Contains genetic information: DNA
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Slide 12 - Each human cell contains 46 chromosomes (except sperm or egg cells)
Slide 13 - Chromosomes in a cell that is about to divide
Slide 14 - Mitochondria: factories of energy
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Slide 16 - The Golgi apparatus cis trans medial  processing of secretory proteins  sorting cellular proteins
Slide 17 - Inside the cytosol: the cytoskeleton “microtubules” maintainance of cell shape and mobility ancor for other cellular structures
Slide 18 - Presentation: DNA
Slide 19 - Cell Cycle and Cell Division
Slide 20 - Some Eukaryotic Cell-Cycle Times
Slide 21 - The eukaryotic cell cycle
Slide 22 - Separation of sister chromatides during mitosis (mitosis = normal cell division)
Slide 23 - Microtubuli: assist chromosomes during cell division (mitosis)
Slide 24 - Different stages of the M phase during cell division (mitosis)
Slide 25 - The three DNA sequence elements needed to produce a eukaryotic chromosome that can be replicated and then segregated at mitosis
Slide 26 - Kinetochores and kinetochore microtubules
Slide 27 - Gametogenesis: meiosis (= specialized form of cell division giving rise to sperm and egg cells) Meiosis I
Slide 28 - Meiosis I (continued) Meiosis II Cell division without DNA replication  Haploid cell
Slide 29 - Presentation: Chromosomes, mitosis and meiosis
Slide 30 - Cellular Molecules
Slide 31 - The four main families of small organic molecules in cells
Slide 32 - Macromolecules are abundant in cells
Slide 33 - The general reaction by which a macromolecule is made Condensation reaction: H2O molecule is released
Slide 34 - The four main families of small organic molecules in cells
Slide 35 - Glucose, a simple sugar
Slide 36 - Monosaccharides
Slide 37 - Sugar ring formation in aqueous solution
Slide 38 - Disaccharides: formed by two sugar monomers
Slide 39 - Oligo- and polysaccharides
Slide 40 - Complex oligosaccharides
Slide 41 - The four main families of small organic molecules in cells
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Slide 45 - Phospholipid structure and orientation of phospholipids in membranes
Slide 46 - The four main families of small organic molecules in cells
Slide 47 - A simple amino acid: alanine
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Slide 49 - A small part of a large protein molecule
Slide 50 - The four main families of small organic molecules in cells
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Slide 53 - ATP: the energy carrier in cells
Slide 54 - Various functions of proteins
Slide 55 - Proteins as polypeptide chains
Slide 56 - Three types of noncovalent bonds that help proteins fold
Slide 57 - The size of proteins
Slide 58 - Several levels of protein organization
Slide 59 - Many protein molecules contain multiple copies of a single protein subunit
Slide 60 - Proteins often have highly specific binding sites
Slide 61 - How a set of enzyme-catalyzed reactions generates a metabolic pathway
Slide 62 - Phosphorylation and ATP hydrolysis drive protein functions
Slide 63 - Genetic information is stored in the DNA
Slide 64 - DNA and its building blocks
Slide 65 - DNA has an orientation
Slide 66 - DNA encodes proteins
Slide 67 - “Genes” encode proteins
Slide 68 - DNA replication
Slide 69 - DNA synthesis and proofreading
Slide 70 - Replication of eukaryotic chromosomes
Slide 71 - The replication fork in detail
Slide 72 - DNA replication can cause mutations
Slide 73 - DNA repair
Slide 74 - Mutations: possible cause of diseases and disfunctionalities
Slide 75 - The Genetic Dogma
Slide 76 - From DNA to protein
Slide 77 - Transcription by RNA polymerase
Slide 78 - RNA vs DNA
Slide 79 - Genes contain introns and exons
Slide 80 - Presentation: Heredity and inheritance