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Slide 1 - Management of psoriasis with Aloe vera extract in hydrophilic cream: a placebo-controlled, double-blind study Syed, Tanweer A. et al. 1996. Tropical Medicine and Internal Health 1:505-509 Presented by: Wislaine Coby
Slide 2 - PURPOSE To test an aloe vera extract 0.5% in a hydrophilic cream on patients with a skin disease called psoriasis compared to other medications.
Slide 3 - RECAP What is psoriasis? A common skin disease that affects millions of children and adults, more common in Caucasians. It’s characterized by thick, dry scales and inflammation of the skin .
Slide 4 - Aloe vera It is a cactus-like succulent perennial with long, grayish-green, prickly edge leaves. Aloe has anti-inflammatory, anti-bacterial, and anti-fungal properties. It heals and help ease the discomfort of minor skin irritations and burns.
Slide 5 - Active Agent Salicylates: a pain reliever and anti-inflammatory Magnesium lactate: inhibits the irration
Slide 6 - METHODS AND MATERIALS 36 males and 24 females ranging from the age of 18-50 having mild to moderate psoriasis for at least 8 years. Aloe vera extract (0.5%) in a hydrophilic cream with a combination of mineral oil and castor oil. A double-blind, placebo control study
Slide 7 - Patients had to apply the cream 3 times daily for five consecutive days. Each patient received a 100 g tube of the treatment which had to remain at a constant temperature. Active treatment done only for 4 weeks.
Slide 8 - For 16 weeks, patients were examined once a week. Then they were followed up on a monthly basis for 8 months.
Slide 9 - RATIONALE Lots of follow ups had to be done to observe any improvements or the severity of the medications
Slide 10 - RESULTS All 60 patients stayed in the study, none withdrew. A reduction of desquamation, peeling of the top layer skin. 27/60 patients were showed improvement.
Slide 11 - 356/762 plaques on the body were cured. There was a low PASI score (psoriasis area and severity index), showing a mean of 9.3 to 2.2. No hypersensitivity or drug related adverse symptoms.
Slide 12 - Patients’ Characteristics
Slide 13 - Effectiveness of the aloe extract The extract was absorbed into the dermal and tissues area of the skin. Kept the skin moist and inhibited the plaques by suppressing proliferation and stimulatory differentiation of the cells.
Slide 14 - Comparing the aloe with calcipotriol Calcipotriol is a synthetic vitamin D analogue (most commonly used). It induces terminal epidermal differentiation and inhibits epidermal proliferation.
Slide 15 - Experiment done There was a total of 50 patients. 30 patients in the 4 week trial and 20 in the 6 week trial. Different concentrations of calcipotriol was used daily.
Slide 16 - RESULTS In the 4 week trial 88% were were cured, but some developed side effects and with drew from the study In the 6 week trial 85% were cured but 2 patients developed adverse effects.
Slide 17 - CONCLUSION The aloe vera extract 0.5% in hydrophilic cream was very effective and tolerable . There were no side effects, adverse symptoms or withdrawals. The placebo was not effective because the patients showed no changes. Calcipotriol was not effective because there were side effects and withdraws with this treatment.
Slide 18 - Aloe vera 0.5% in a hydrophilic cream will be the new medication to treat psoriasis. Patients suffering from this disease will live a better life.
Slide 19 - REFERENCES Scheer, James F. 1998. Aloe: A summer must-have & so much more. Better Nutrition 60:50-52. Stern, Robert. 1997. Psoriasis. The Lancet 350:349-353. Syed, Tanweer A. et al. 1996. Management of psoriasis with Aloe vera extract in hydrophilic cream: a placebo-controlled, double-blind study. Trop Med Int Health 1:505-509