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Liver cancer Hepatocellular carcinoma PowerPoint Presentation

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On : Feb 24, 2014

In : Health & Wellness

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  • Slide 1 - Hepatocellular carcinoma Diagnosis, Treatment, Prognosis + Quiz Vinko Bubic Mentor: A. Žmegač Horvat
  • Slide 2 - Diagnosis Physical examination - enlarged, tender liver Elevated serum alpha fetoprotein (normally : 40mg/l) Elevated liver enzymes (ALT, AST, Alpha-1 antitrypsin, serum bilirubin, urine bilirubin...)
  • Slide 3 - Diagnosis CT
  • Slide 4 - CT Computed tomography - medical imaging method employing tomography (imaging by sections or sectioning) Large series of two-dimensional X-ray images taken around a single axis of rotation, computer integration Iodine dye through vein for better visualisation (allergy)
  • Slide 5 - ppt slide no 5 content not found
  • Slide 6 - MRI Magnetic resonance imaging The body - mainly composed of water molecules Electromagnetic field causes protons to absorb some of its energy Scanner detects release of proton energy (tumor tissue releases different frequency) Greater contrast than CT
  • Slide 7 - Modern 3T MRI
  • Slide 8 - Biopsy Definitive diagnosis of hepatocellular carcinoma
  • Slide 9 - Hyperchromatic, clear cells with large red cytoplasm
  • Slide 10 - Treatment Liver transplatation (cadaver liver or live donor lobe) Surgical resection (best prognosis for long-term survival, but possible in only 10-15% of cases)
  • Slide 11 - Treatment Percutaneus ethanol injection - small (< 3 cm) solitary tumors Transcatheter arterial chemoembolization (TACE) - more than 3 cm and less than 4 cm in diameter Sealed source radiotherapy (brachytherapy) - radioactive source is placed inside or next to area requiring treatment
  • Slide 12 - Prior to ethanol ablation After
  • Slide 13 - Transcatheter arterial chemoembolization
  • Slide 14 - Other techniques Radiofrequency ablation (RFA) High intensity focused ultrasound (HIFU) Chemotherapy (antiestrogen + tamoxifen) Cryosurgery - destruction of abnormal tissue using sub-zero temperatures
  • Slide 15 - HIFU
  • Slide 16 - Cryosurgery Iceball
  • Slide 17 - HCC complications Gastrointestinal bleeding Cachexy Portal hypertension -> esophageal bleeding Liver failure Metastasis (lymph nodes around pancreas, aorta, lungs, adrenal glands, bones) Rupture of tumor -> abdominal bleeding
  • Slide 18 - Prognosis Usually poor outcome Only 10 - 20% of hepatocellular carcinomas can be removed completely If not, disease usually deadly within 3 to 6 months
  • Slide 19 - Quiz: The definitive HCC diagnosis is confirmed by: a) spider nevus by inspection b) auscultation c) biopsy and microscopy d) MRI e) esophageal reflux
  • Slide 20 - Ethanol: a) dehydrates cells b) hydrates cells and cracks them c) activates IL-8 d) causes apoptosis e) nothing from above
  • Slide 21 - In cryotherapy, tumor is frozen by: a) flucloxacillin b) Iodine c) liquid nitrogen d) surgeon’s eye e) cocaine
  • Slide 22 - What did you eat today? This maybe? 
  • Slide 23 - Thanks ! ! !
  • Slide 24 - References: http://www.cancer.gov/cancertopics/types/liver/ http://www.mayoclinic.com/health/liver-cancer/DS00399 Medicinski leksikon, Leksikografski zavod “Miroslav Krleža”, Zagreb 1992. PATOLOGIJA, urednici Damjanov, Jukic, Nola, izdanje 2007.

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Tags : liver cancer | hepatocellular carcinoma | cancer | liver | liver cancer disease

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