This site uses cookies to deliver our services and to show you relevant ads and presentations. By clicking on "Accept", you acknowledge that you have read and understand our Cookie Policy , Privacy Policy , and our Terms of Use.
X

Download Leukoreduction in red blood cell transfusion PowerPoint Presentation


Login   OR  Register
X


Iframe embed code :



Presentation url :

X

Description :

Available Leukoreduction in red blood cell transfusion powerpoint presentation for free download which is uploaded by search an active user in belonging ppt presentation Health & Wellness category.

Tags :

Leukoreduction in red blood cell transfusion

Home / Health & Wellness / Health & Wellness Presentations / Leukoreduction in red blood cell transfusion PowerPoint Presentation

Leukoreduction in red blood cell transfusion PowerPoint Presentation

Ppt Presentation Embed Code   Zoom Ppt Presentation

About This Presentation


Description : Available Leukoreduction in red blood cell transfusion powerpoint presentation for free download whi... Read More

Tags : Leukoreduction in red blood cell transfusion

Published on : Mar 14, 2014
Views : 586 | Downloads : 0


Download Now

Share on Social Media

             

PowerPoint is the world's most popular presentation software; you can create professional Leukoreduction in red blood cell transfusion powerpoint presentation with this powerful software easly. And give your presentation on Leukoreduction in red blood cell transfusion in conference, a school lecture, a business proposal or in webinar.

Uploader spend their valuable time to create this Leukoreduction in red blood cell transfusion powerpoint presentation slides, to share their knowledgable content with the world. This ppt presentation uploaded by onlinesearch in their relavent Health & Wellness category is available for free download and use according to your industries likefinance,marketing,education,health and many more.

SlidesFinder.com provides a platform for marketers, presenters and educationists along with being the preferred search engine for professional PowerPoint presentations on the Internet to upload your Leukoreduction in red blood cell transfusion ppt presentation slides to BUILD YOUR CROWD!!

User Presentation
Related Presentation
Free PowerPoint Templates
Slide 1 - 1
Slide 2 - Leukoreduction in Red Blood Cell Transfusion By Dr. Amr Mohamed Mahmoud
Slide 3 - Etymology The name "white blood cell“ is derived from the fact that after centrifugation of a blood sample, the white cells are found in the buffy coat, a thin, typically white layer of nucleated cells between the sedimented red blood cells and the blood plasma. The scientific term leukocyte directly reflects this description, derived from Ancient Greek λευκό (white), and κύτταρο (cell).
Slide 4 - ppt slide no 4 content not found
Slide 5 - ppt slide no 5 content not found
Slide 6 - Leukocyte content of whole blood averages two billion ( 2 x109 ) leukocytes per 500 mL of whole blood. During blood component preparation : 90% of leukocytes fractionate with the red blood cells (RBCs). 8% is retained within Platelet concentrates. 2% are present in the plasma before freezing.
Slide 7 - Leukocyte reduction can be achieved by various techniques, including : Centrifugation Leukocyte filtration Sedimentation Washing Freeze-thawing Apheresis
Slide 8 - Leukocyte Reduction Filters
Slide 9 - Leukocyte Filters
Slide 10 - Adverse Effects Associated with Donor Leukocytes Nonhemolytic febrile transfusion reactions Transmission of leukocyte-associated viruses cytomegalovirus Alloimmunization Immunomodulatory effects Cancer recurrence Postoperative infections Transfusion storage time for red blood cells Transfusion storage time for platelets Transfusion-related acute lung injury Transfusion-associated graft-versus-host disease
Slide 11 - 1. Febrile Nonhemolytic Transfusion Reactions Definition : as a temperature increase of 1°C after an allogeneic blood transfusion. Cause : alloantibodies in the recipient’s plasma against antigens present on donor leukocytes and/or platelets Incidence: 0.5% in patients receiving a first transfusion 60% in Chronically transfused patients
Slide 12 - 2. Transmission of leukocyte-associated viruses (e.g.cytomegalovirus) Transfusion-associated CMV infection is a significant cause of morbidity and mortality in immuno-compromised patients and especially in organ transplant recipients. After either kidney or liver transplants, more than 60% of patients develop antibodies against CMV.
Slide 13 - 3. Platelet Refractoriness and Alloimmunization Alloimmunization can reduce the clinical effectiveness of platelet transfusions by 50%. Especially prevalent among those : - Patients receiving pooled random donor platelet concentrates. - Who are Pregnant.
Slide 14 - 4. Immunomodulation and Postoperative Infectious Complications Contaminating leukocytes in RBC transfusions might be responsible for down-regulation of : Natural-killer (NK) cell activity, T cell proliferation T lymphocyte antitumor activity CD-4 helper to CD-8 suppressor ratio Lymphocyte blastogenesis
Slide 15 - 5. Cancer Recurrence An association between allogeneic blood transfusion and colorectal cancer recurrence after surgery. Blood transfusions in colorectal surgery patients have been reported to increase cancer recurrence by 37%also have been associated with increased recurrence of breast, lung, kidney, prostate, stomach, cervical, laryngeal, soft tissue, and bone malignancies.
Slide 16 - 6. Postoperative infections Transfusion of blood components containing bacteria may lead to potentially fatal sepsis. Cause : inadequate skin preparation before venipuncture. Common pathogens : include Gram-negative endotoxin producing organisms such as Yersinia enterocolitica, pseudomonas and enterobacter
Slide 17 - 6. Postoperative infections Optimal storage time before filtration to allow for maximal leukocyte ingestion of bacteria appeared to be between 2 and 12 hours. The beneficial effect of leukocyte reduction may lie in removal of leukocytes containing ingested bacteria.
Slide 18 - Decrease ATP. Glucose consumption. Increase lactate and k+ production. The presence of leukocytes in blood components reduces glucose availability. leukocyte lysis leads to release of cytokines that reduce RBC survival. 7. Transfusion storage time for red blood cells
Slide 19 - Decreases in pH Increases in glucose consumption Lactate production Lactic dehydrogenase release Platelets stored with leukocytes express decreased quantities of glycoprotein Ib (GPIb) receptor, resulting in a bleeding disorders. 8. Transfusion storage time for platelets
Slide 20 - 9. Transfusion-related acute lung injury Stored blood contains micro-aggregates of degenerated leukocytes, platelets and fibrin These micro-aggregates have been associated with pulmonary insufficiency due to agglutination of donor leukocytes by recipient antibodies. C/P : severe dyspnea, non-cardiogenic pulmonary edema.
Slide 21 - 10. Transfusion-associated graft-versus-host disease (GVHD) GVHD is a potentially lethal condition. Cause : donor T lymphocytes. Mechanism : immunocompromised recipients, host defense mechanisms fail to suppress viable transfused donor lymphocytes, which engraft within the recipient’s marrow, ultimately resulting in death. Occurrence : 1. when the donor and recipient share an HLA haplotype. 2. Use of directed-donor blood from first degree relatives. Prophylaxis : gamma-irradiation.
Slide 22 - Few side effects have been reported Hypotension : due to release of bradykinin like vasoactive substance esp. in patients receiving ACEI prolong intravascular half life of bradykinin : by decreasing bradykinin degradation. Complement activation and formation of platelets aggregate 2%-8% decrease in potency of cellular components of blood. Adverse Effects of Leukocyte Reduction
Slide 23 - 3. Red eye syndrome ( allergic conjunctivitis). - Erythema 100%. - Periorbital edema 16% - Eye pain 15% - Itching Symptoms resolve 48 hours but erythema may require up to 3 weeks.
Slide 24 - ppt slide no 24 content not found