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Slide 1 - HEART-LUNG TRANSPLANTATION Overall 2011 ISHLT
Slide 2 - NUMBER OF HEART-LUNG TRANSPLANTS REPORTED BY YEAR NOTE: This figure includes only the heart-lung transplants that are reported to the ISHLT Transplant Registry. As such, this should not be construed as evidence that the number of heart-lung transplants worldwide has declined in recent years. ISHLT 2011
Slide 3 - AVERAGE CENTER VOLUMEHeart-Lung Transplants: January 1, 1998 - June 30, 2010 ISHLT 2011
Slide 4 - DISTRIBUTION OF HEART-LUNG TRANSPLANTS BY CENTER VOLUMEHeart-Lung Transplants: January 1, 1998 - June 30, 2010 ISHLT 2011
Slide 5 - DISTRIBUTION OF HEART-LUNG TRANSPLANTS BY LUNG CENTER VOLUMELung Transplants: January 1, 1998 - June 30, 2010 ISHLT 2011
Slide 6 - HEART-LUNG TRANSPLANTATIONKaplan-Meier Survival for All Ages (Transplants: January 1982 - June 2009) ISHLT 2011
Slide 7 - HEART-LUNG TRANSPLANTATION Adult Recipients ISHLT 2011
Slide 8 - DIAGNOSIS IN ADULT HEART-LUNG TRANSPLANTS (January 1982 - June 2010) “Other” includes cancer, LAM, OB, sarcoidosis, bronchiectasis ISHLT 2011
Slide 9 - DIAGNOSIS IN ADULT HEART-LUNG TRANSPLANTS (Transplants: January 1982 - June 2010) ISHLT 2011
Slide 10 - DIAGNOSIS IN ADULT HEART-LUNG TRANSPLANTS BY ERA (Transplants: January 1982 - June 2010) “Other” includes OB (non-ReTX) and Bronchiectasis ISHLT 2011
Slide 11 - ADULT HEART-LUNG TRANSPLANTATIONMajor Indications By Year (%) ISHLT 2011
Slide 12 - ADULT HEART-LUNG TRANSPLANTATIONMajor Indications By Year (Number) ISHLT 2011
Slide 13 - ADULT HEART-LUNG TRANSPLANTS:AGE DISTRIBUTION BY LOCATION Transplants between January 2000 and June 2010 ISHLT 2011
Slide 14 - ADULT HEART-LUNG TRANSPLANTS:DIAGNOSIS DISTRIBUTION BY LOCATION Transplants between January 2000 and June 2010 ISHLT 2011
Slide 15 - ADULT HEART-LUNG TRANSPLANTS:DONOR AGE DISTRIBUTION BY LOCATION Transplants between January 2000 and June 2010 ISHLT 2011
Slide 16 - HEART-LUNG TRANSPLANTATIONKaplan-Meier Survival for Adult Recipients (Transplants: January 1982 - June 2009) ISHLT 2011
Slide 17 - HEART-LUNG TRANSPLANTATIONKaplan-Meier Survival for Adult Recipients by Era (Transplants: January 1982 - June 2009) ISHLT 2011
Slide 18 - ADULT HEART-LUNG TRANSPLANTATIONKaplan-Meier Survival By Diagnosis (Transplants: January 1990 – June 2009) ISHLT 2011
Slide 19 - ADULT HEART-LUNG TRANSPLANTATIONKaplan-Meier Survival By Diagnosis Conditional on Survival to 1 Year (Transplants: January 1990 – June 2009) ISHLT 2011
Slide 20 - ADULT HEART-LUNG RECIPIENTS Cross-Sectional Analysis Functional Status of Surviving Recipients (Follow-ups: April 1994 – June 2010) ISHLT 2011
Slide 21 - ADULT HEART-LUNG RECIPIENTS Functional Status of Surviving Recipients US Recipients Only(Follow-ups: March 2005 - June 2010) ISHLT 2011
Slide 22 - ADULT HEART-LUNG RECIPIENTSEmployment Status of Surviving Recipients(Follow-ups: April 1994 – June 2010) ISHLT 2011
Slide 23 - ADULT HEART-LUNG RECIPIENTS: Rehospitalization Post-transplant of Surviving Recipients (Follow-ups: April 1994 - June 2010) ISHLT 2011
Slide 24 - ADULT HEART-LUNG RECIPIENTS Induction ImmunosuppressionFor transplants between January 2001 through June 2010 ISHLT 2011 Analysis is limited to patients who were alive at the time of the discharge
Slide 25 - ADULT HEART-LUNG RECIPIENTSInduction Immunosuppression (Transplants: January 2000 - December 2009) ISHLT 2011 Analysis is limited to patients who were alive at the time of the discharge
Slide 26 - ADULT HEART-LUNG RECIPIENTSInduction Immunosuppression (Transplants: January 2000 - December 2009) Any Induction Polyclonal ALG/ATG OKT3 IL-2R Antagonist ISHLT 2011 Analysis is limited to patients who were alive at the time of the discharge
Slide 27 - ADULT HEART-LUNG RECIPIENTSMaintenance Immunosuppression at Time of Follow-upFor follow-ups between January 2001 through June 2010 NOTE: Different patients are analyzed in Year 1 and Year 5 Analysis is limited to patients who were alive at the time of the follow-up ISHLT 2011
Slide 28 - ADULT HEART-LUNG RECIPIENTSMaintenance Immunosuppression Drug Combinations at Time of Follow-upFor follow-ups between January 2001 through June 2010 NOTE: Different patients are analyzed in Year 1 and Year 5 Analysis is limited to patients who were alive at the time of the follow-up ISHLT 2011
Slide 29 - POST-HEART-LUNG TRANSPLANT MORBIDITY FOR ADULTS Cumulative Prevalence in Survivors within 1 Year Post-Transplant (Follow-ups: April 1994 - June 2010) ISHLT 2011
Slide 30 - POST-HEART-LUNG TRANSPLANT MORBIDITY FOR ADULTS Cumulative Prevalence in Survivors within 5 Years Post-Transplant (Follow-ups: April 1994 - June 2010) ISHLT 2011
Slide 31 - Freedom from Coronary Artery Vasculopathy and Bronchiolitis Obliterans SyndromeFor Adult Heart-Lung Recipients (Follow-ups: April 1994-June 2010) ISHLT 2011
Slide 32 - Freedom from Coronary Artery Vasculopathy For Adult Heart-Lung Recipients By Diagnosis Type (Follow-ups: April 1994-June 2010) P-value comparing all = 0.4542 ISHLT 2011
Slide 33 - Freedom from Bronchiolitis Obliterans Syndrome For Adult Heart-Lung Recipients By Diagnosis Type (Follow-ups: April 1994-June 2010) P-value comparing all = 0.7620 ISHLT 2011
Slide 34 - Freedom from Severe Renal Dysfunction*For Adult Heart-Lung Recipients (Follow-ups: April 1994-June 2010) ISHLT 2011
Slide 35 - MALIGNANCY POST-HEART-LUNG TRANSPLANT FOR ADULTSCumulative Prevalence in Survivors (Follow-ups: April 1994-June 2010) * Recipients may have experienced more than one type of malignancy so sum of individual malignancy types may be greater than total number with malignancy. ISHLT 2011
Slide 36 - Freedom from MalignancyFor Adult Heart-Lung Recipients (Follow-ups: April 1994- June 2010) ISHLT 2011
Slide 37 - ADULT HEART-LUNG TRANSPLANT RECIPIENTS: Cause of Death (Deaths: January 1992 - June 2010) ISHLT 2011
Slide 38 - ADULT HEART-LUNG TRANSPLANT RECIPIENTS: Relative Incidence of Leading Causes of Death(Deaths: January 1992 - June 2010) ISHLT 2011
Slide 39 - HEART-LUNG TRANSPLANTATION Pediatric Recipients ISHLT 2011
Slide 40 - AGE DISTRIBUTION OF PEDIATRIC HEART-LUNGRECIPIENTS (Transplants: January 1982 - June 2010) ISHLT 2011
Slide 41 - AGE DISTRIBUTION FOR DONORS OF PEDIATRIC HEART-LUNG RECIPIENTS (Transplants: January 1982 - June 2010) ISHLT 2011
Slide 42 - AGE DISTRIBUTION OF PEDIATRIC HEART-LUNG RECIPIENTSBy Year of Transplant Number of Transplants NOTE: This figure includes only the heart-lung transplants that are reported to the ISHLT Transplant Registry. As such, this should not be construed as evidence that the number of pediatric heart-lung transplants worldwide has declined in recent years. ISHLT 2011
Slide 43 - AGE DISTRIBUTION OF PEDIATRIC HEART-LUNG RECIPIENTSBy Era of Transplant Percentage of Transplants ISHLT 2011
Slide 44 - NUMBER OF CENTERS REPORTING PEDIATRIC HEART-LUNG TRANSPLANTS NEED TO UPDATE ISHLT 2011
Slide 45 - NUMBER OF CENTERS REPORTING PEDIATRIC HEART-LUNG TRANSPLANTSStratified by center volume ISHLT 2011
Slide 46 - DIAGNOSIS IN PEDIATRIC HEART-LUNG TRANSPLANT RECIPIENTS (Transplants: 1986-2009) “Other” includes Bronchiectasis, Alpha-1, and OB (non-ReTX) NOTE: Unknown diagnoses were excluded from this tabulation. ISHLT 2011
Slide 47 - PEDIATRIC HEART-LUNG TRANSPLANTS:AGE DISTRIBUTION BY LOCATIONTransplants between January 2000 and June 2010 ISHLT 2011
Slide 48 - PEDIATRIC HEART-LUNG TRANSPLANTS:DIAGNOSIS DISTRIBUTION BY LOCATION Transplants between January 2000 and June 2010 ISHLT 2011
Slide 49 - PEDIATRIC HEART-LUNG TRANSPLANTS:DONOR AGE DISTRIBUTION BY LOCATIONTransplants between January 2000 and June 2010 ISHLT 2011
Slide 50 - PEDIATRIC HEART-LUNG TRANSPLANTATIONKaplan-Meier Survival By Diagnosis (Transplants: January 1990 – June 2009) ISHLT 2011
Slide 51 - PEDIATRIC HEART-LUNG TRANSPLANTATION Kaplan-Meier Survival (Transplants: January 1982 - June 2009) ISHLT 2011
Slide 52 - PEDIATRIC HEART-LUNG TRANSPLANTATION Kaplan-Meier Survival by Era (Transplants: January 1982 - June 2009) ISHLT 2011
Slide 53 - PEDIATRIC HEART-LUNG TRANSPLANTATION Kaplan-Meier Survival by Era (Transplants: January 1982 - June 2009)Conditional on Survival to 1 Year ISHLT 2011
Slide 54 - PEDIATRIC HEART-LUNG TRANSPLANT RECIPIENTS: Cause of Death (Deaths: January 1992 - June 2010) ISHLT 2011
Slide 55 - PEDIATRIC HEART-LUNG TRANSPLANT RECIPIENTS: Cause of Death (Deaths: April 1994 - June 2010) ISHLT 2011
Slide 56 - PEDIATRIC HEART-LUNG TRANSPLANT RECIPIENTS: Relative Incidence of Leading Causes of Death(Deaths: April 1994 - June 2010) ISHLT 2011