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Diagram of the Blood Clotting Cascade

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Published on : Dec 09, 2014
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Slide 1 - The Blood Clotting Cascade Manfred Maitz FZ-Rossendorf www.manfred.maitz-online.de
Slide 2 - The Clotting Cascade
Slide 3 - The Clotting Cascade
Slide 4 - Serine Proteases
Slide 5 - The Fibrinolytic System Fibrin degradation products Fibrinogen Fibrin-clot Plasmin Plasminogen T-PA F XIIa HMWK Kallikrein Urokinase Streptokinase Clotting Cascade
Slide 6 - Effect of Antithrombin III/Heparin Fibrinogen Fibrin monomers Prothrombin I Thrombin Factor F Xa Factor F X Factor F X F VII F VIIa F IXa F IX F XIa F XI Surface Contact Collagen FXII activator F XIIa F XII F III (Tissue Thromboplastin) Tissue/Cell Defect Intrinsic Pathway Extrinsic Pathway Platelet Factor 3 Ca2+ Ca2+ Ca2+ Ca2+ Ca2+ Fibrin polymers Crosslinked Fibrin Meshwork F XIIIa F XIII F VIIIa F VIII Ca2+
Slide 7 - Thrombin Time (TT) Fibrinogen Fibrin monomers Prothrombin I Thrombin Factor F Xa Factor F X Factor F X F VII F VIIa F IXa F IX F XIa F XI Surface Contact Collagen FXII activator F XIIa F XII F III (Tissue Thromboplastin) Tissue/Cell Defect Intrinsic Pathway Extrinsic Pathway Platelet Factor 3 Ca2+ Ca2+ Ca2+ Ca2+ Ca2+ Fibrin polymers Crosslinked Fibrin Meshwork F XIIIa F XIII F VIIIa F VIII Ca2+
Slide 8 - The Quick (PT)-Test Fibrinogen Fibrin monomers Prothrombin I Thrombin Factor F Xa Factor F X Factor F X F VII F VIIa F IXa F IX F XIa F XI Surface Contact Collagen FXII activator F XIIa F XII F III (Tissue Thromboplastin) Tissue/Cell Defect Intrinsic Pathway Extrinsic Pathway Platelet Factor 3 Ca2+ Ca2+ Ca2+ Ca2+ Ca2+ Fibrin polymers Crosslinked Fibrin Meshwork F XIIIa F XIII F V F Va F VIIIa F VIII Ca2+
Slide 9 - Partial Thromboplastin Time [(a)PTT] Fibrinogen Fibrin monomers Prothrombin I Thrombin Factor F Xa Factor F X Factor F X F VII F VIIa F IXa F IX F XIa F XI Surface Contact Collagen FXII activator F XIIa F XII F III (Tissue Thromboplastin) Tissue/Cell Defect Intrinsic Pathway Extrinsic Pathway Platelet Factor 3 Ca2+ Ca2+ Ca2+ Ca2+ Ca2+ Fibrin polymers Crosslinked Fibrin Meshwork F XIIIa F XIII F V F Va F VIIIa F VIII Ca2+
Slide 10 - Surface Sensitive Steps Fibrinogen Fibrin monomers Prothrombin I Thrombin Factor F Xa Factor F X Factor F X F VII F VIIa F IXa F IX F XIa F XI Surface Contact Collagen FXII activator F XIIa F XII F III (Tissue Thromboplastin) Tissue/Cell Defect Intrinsic Pathway Extrinsic Pathway Platelet Factor 3 Ca2+ Ca2+ Ca2+ Ca2+ Ca2+ Fibrin polymers Crosslinked Fibrin Meshwork F XIIIa F XIII F VIIIa F VIII Ca2+