X

Download Cholesterol Metabolism PowerPoint Presentation


Login   OR  Register
X

Share page



  Preview

               
Home / Health & Wellness / Health & Wellness Presentations / Cholesterol Metabolism PowerPoint Presentation

Cholesterol Metabolism PowerPoint Presentation

slidesfinder By : slidesfinder

On : Dec 06, 2013

facebook   twitter   google plus  
In : Health & Wellness

Embed :
756
views

0
downloads
Login / Signup - with account for


  • → Make favorite
  • → Flag as inappropriate
  • → Download Presentation
  • → Share Presentation
  • Slide 1 - Cholesterol Metabolism Sources of cholesterol Cholesterol synthesis Long and short term regulation SREBP-2 Lowering cholesterol Calculating your risk for CHD
  • Slide 2 - Roles of Cholesterol Membrane component Steroid synthesis Bile acid/salt precursor Vitamin D precursor
  • Slide 3 - Sources of Cholesterol Diet De novo synthesis Cholesterol synthesized in extrahepatic tissues Liver cholesterol pool Free cholesterol In bile Conversion to bile salts/acids Secretion of HDL and VLDL
  • Slide 4 - Cholesterol Structure FA for esterification
  • Slide 5 - Dietary Cholesterol Animal products – eggs Absorb about 50% Increase intake = decreased absorption Excrete – 1 g/day (bile acids)
  • Slide 6 - Dietary Cholesterol Assume 400 mg intake / day 200 mg is absorbed 1000 mg is excreted 800 mg from de novo synthesis Lowering cholesterol in diet has very little effect on blood cholesterol !!!
  • Slide 7 - Cholesterol Synthesis Similar to ketogenic pathway Occurs in cytosol Requires NADPH and ATP Highly regulated 80 % in liver, ~10% intestine, ~5% skin
  • Slide 8 - Cholesterol Synthesis
  • Slide 9 - HMG CoA Reductase : Regulation Short-term regulation Inhibited by phosphorylation AMP-dependent protein kinase When AMP is high (or ATP low!), why waste energy on cholesterol synthesis Long-term regulation Proteolysis Degradation stimulated by cholesterol and cholesterol metabolites Sterol-sensing domain
  • Slide 10 - HMG CoA reductase - Phosphorylation AMP-Activated Protein Kinase (high activity) AMP-Activated Protein Kinase (low activity) phosphatase insulin (+) kinase Glucagon/epi (+) increase cAMP AMP (+) HMG CoA reductase – OH (active) HMG CoA reductase – P (inactive)
  • Slide 11 - Transcriptional regulation SREBP-2 Responds to cellular levels of sterols HMG CoA Reductase : Regulation
  • Slide 12 - SREBP cleavage activating protein
  • Slide 13 - Site 1 and site 2 protease -
  • Slide 14 - ppt slide no 14 content not found
  • Slide 15 - Free Cholesterol Pool synthesis Negative Feedback (-) LDL receptor LP Negative Feedback (-) acat CE HDL Steroid synthesis C
  • Slide 16 - Lowering Cholesterol Statins – decrease HMG CoA reductase activity Muscle weakness Why?
  • Slide 17 - Bile sequestering agents Lowering Cholesterol Bile acids liver Bile acids 95 % reabsorbed 5% in feces Bind bile acid Utilize more cholesterol to make bile acids >10% in feces
  • Slide 18 - Lowering Cholesterol Oat bran Soluble fiber Bind bile acids? Niacin 3-8 grams / day (need 60 mg) Inhibits VLDL excretion ? (fatty liver) Flushing and liver damage
  • Slide 19 - Unsaturated fats and Cholesterol
  • Slide 20 - Calculate your risk

Description : View and free download Cholesterol Metabolism powerpoint presentation which is uploaded by honey an active user in belonging ppt presentation Health & Wellness category.

Tags : Cholesterol Metabolism

Shortcode : Get Shareable link