Slide 9 -
Whole Brain Radio therapy WBRT after surgery reduce the rate of recurrence and possibly prolong survival.
[Wen, PY, Loeffler, JS. Management of brain metastases. Oncology (Huntingt) 1999; 13:941.] [Skibber, JM, Soong, SJ, Austin, L, et al. Cranial irradiation after surgical excision of brain metastases in melanoma patients. Ann Surg Oncol 1996; 3:118.] Treatment Chemotherapy Brain Metastases from melanoma are generally resistant to chemotherapy. But, fotemustine and temozolomide have a possibility of treatment. [Jacquillat, C, Khayat, D, Banzet, P, et al. Final report of the French multicenter phase II study of the nitrosourea fotemustine in 153 evaluable patients with disseminated malignant melanoma including patients with cerebral metastases. Cancer 1990; 66:1873.] [Hwu, WJ, Lis, E, Menell, JH, et al. Temozolomide plus thalidomide in patients with brain metastases from melanoma. Cancer 2005; 103:2590. ]