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Alcoholic liver disease PowerPoint Presentation

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Published on : Mar 14, 2014
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Slide 1 - "With ordinary talent and extraordinary perseverance, all things are attainable." - Thomas E. Buxton "Achievement is connected with action, not in genes..…!” - Conrad Hilton
Slide 2 - Alcoholic liver disease
Slide 3 - Excessive alcohol consumption is the leading cause of liver disease. Alcoholic liver disease comprises of three main stages Hepatic steatosis Alcoholic hepatitis Cirrhosis
Slide 4 - Hepatic steatosis Pathogenesis : Fatty change is an acute, reversible manifestation of ethanol ingestion. Ethanol causes Increased fatty acid synthesis by causing catabolism of fat in the peripheral tissues Acetaldehyde which is metabolite of ethanol converts NAD+ to NADH. An excess NADH stimulates lipid biosynthesis. Oxidation of fatty acid by mitochondria is decreased Acetaldehyde impairs the function of microtubules, resulting in decreased transport of lipoproteins from liver Collectively these metabolic consequences produce fatty liver.
Slide 5 - Pathology: Gross: The liver becomes yellow, greasy and is enlarged (up to 4 to 6 kg) The increase in weight is because of accumulation of fat, protein and water
Slide 6 - Alcoholic Fatty Liver
Slide 7 - Microscopy: Following even moderate intake of alcohol, small (microvesicular) lipid droplets accumulates in the liver With chronic intake of alcohol, more lipid accumulates, creating a large macrovesicular globules, compressing the nucleus the periphery.
Slide 8 - Steatosis in Alcoholism
Slide 9 - Alcoholic Fatty Liver
Slide 10 - Clinical features of alcoholic steatosis Hepatomegaly Mild elevation of serum bilirubin, alkaline phasphatase and gamma GT
Slide 11 - Alcoholic hepatitis Is characterized by Hepatocyte swelling and necrosis Mallory bodies Neutrophilic inflammatory response Perivenular fibrosis
Slide 12 - Hepatocyte swelling and necrosis: Single or scattered foci of cells undergo swelling (ballooning degeneration) and necrosis
Slide 13 - Mallory bodies: Scattered hepatocytes accumulate cytokeratin intermediate filaments and other proteins Visible as eosinophilic cytoplasmic inclusions in degenerating hepatocytes
Slide 14 - Neutrophilic reaction: Neutrophils accumulate around the degenerating hepatocytes, particularly those having Mallory bodies. Lymphocytes and macrophages also enter portal tracts and spill into parenchyma
Slide 15 - Fibrosis : Commonly seen in the form of sinusoidal and perivenular fibrosis Occasionaly periportal fibrosis may predominate Fibrosis mainly occurs because of the activation of sinusoidal stellate cells and portal tract fibroblasts
Slide 16 - Clinical features: Malaise, anorexia, weight loss, upper abdominal discomfort, tender hepatomegaly. Laboratory findings: Hyperbilirubinemia Elevated ALP,GGT, moderate elevation of AST Neutrophilic leucocytosis
Slide 17 - Alcoholic cirrhosis: The final and irreversible form of alcoholic liver disease Usually evolves slowly Gross: Initially the liver is yellow-tan, fatty and enlarged. Later it is transformed into brown, shrunken, nonfatty organ with multiple nodules. Sometimes nodularity becomes very prominent with scattred lager nodules creating a “hobnail” appearance on the surface of liver
Slide 18 - Normal Liver
Slide 19 - Cirrhosis
Slide 20 - Micronodular cirrhosis:
Slide 21 - Alcoholic Cirrhosis
Slide 22 - Microscopy: Initially fibrous septae are very delicate and extend through sinusoids from central to portal regions as well as from portal tract to portal tract. As the fibrous septae dissect and surround nodules, the liver becomes more fibrotic, loses fat, and shrinks in size. (Laennec cirrhosis) Bile stasis may be seen.
Slide 23 - Normal Liver Histology
Slide 24 - Cirrhosis Fibrosis Regenerating Nodule
Slide 25 - Liver Biopsy – Cirrhosis
Slide 26 - Cirrhosis in Alcoholism
Slide 27 - Clinical features: Features are similar to other forms of cirrhosis. Malaise, weakness, weight loss, loss of appetite Jaundice, ascites, and peripheral edema Features of portal hypertension Laboratory findings: Hyperbilirubinemia, elevated serum aminotransferase, alkaline phasphatase, hypoproteinemia and anaemia
Slide 28 - Alcoholic Liver Damage
Slide 29 - Liver abscesses
Slide 30 - Introduction Liver abscesses can result from bacterial infection (pyogenic abscess) or from Entamoeba histolytica. Pyogenic abscesses have a high mortality rate of 40%.  Liver abscesses generally result from spread of infection from : the digestive tract via the portal vein, from biliary disease or by direct extension from an adjacent infection.  Risk factors include: Biliary disease Trauma Diabetes Malignancy.
Slide 31 - Aetiology of liver abscess Enteric Gram-negative bacilli (aerobes and anaerobes) are frequently cultured.  Many of the causative organisms originate in the gastrointestinal tract: Escherichia coli Klebsiella pneumoniae Bacteroides spp. Enterococcus spp. Anaerobic Streptococcus spp. Streptococcus ‘milleri’ group.
Slide 32 - Diagnosis of liver abscess Signs and symptoms include: Fever Anorexia Nausea Weight loss Weakness Upper right quadrant pain Jaundice is rare until a late stage of the infection.
Slide 33 - Laboratory diagnosis Diagnostic investigations include: Culture of aspirated material (under ultrasound guidance) is the most useful diagnostic test With the advent of modern systems and improved media, particularly for the recovery of anaerobic organisms, blood culture is often helpful. Imaging CT is the most useful imaging technique, with ultrasound effective for lesions more than a couple of centimetres in diameter.
Slide 34 - Amoebic liver abscess Amebiasis is a disease caused by a one-celled parasite called Entamoeba histolytica . Mode of transmission: feco-oral with ingestion of amoebic cysts.
Slide 35 - Symptoms of amoebic liver abscess Pain Enlarged liver with maximal tenderness over abscess Intermittent fever (38-39°C) Night sweats Weight loss Nausea Vomiting Cough Dyspnoea
Slide 36 - Symptoms of amebiasis The symptoms often are quite mild and can include loose stools, stomach pain, and stomach cramping. Amebic dysentery is a severe form of amebiasis associated with stomach pain, bloody stools, and fever. Rarely, E. histolytica invades the liver and forms an abscess. Even less commonly, it spreads to other parts of the body, such as the lungs or brain.
Slide 37 - Pathogenesis & pathology : Amoebic liver abscess is always preceded by intestinal colonisation of the protozoan. Trophozoites invade veins to reach the liver through the portal system. Inoculation of amoebae into the liver results in acute inflammation & necrosis of hepatocytes. The necrotic contents of the liver “abscess” are described as “anchovy-sauce” OR “chocolate-paste”.
Slide 38 - Trophozoites of entamoeba histolytica:
Slide 39 - The liver parenchyma is replaced by necrotic tissue surrounded by a thin rim of congested hepatic tissue, having a “shaggy” appearance due to fibrin.
Slide 40 - Complications of amoebic liver abscess(ALA): ALA has a high mortality rate when associated with other-organ involvement. The abscess can rupture into : the pleural space, lung, peritoneal cavity, pericardial cavity and the sub-phrenic space forming amoebic abscesses in these sites.
Slide 41 - ‘Time’ is the best kept secret of the rich..! – Jim Rohn